题目：Flexible Implantable Optogenetic Devices for Multi-brain Network Modulation and Perception Delivery

时间：2024年6月24日 13:30-14:30

地点：机械与动力工程学院 F203会议室

邀请人：胡永祥 教授

报告人简介

杨翌元，2021年在美国西北大学获得机械工程博士学位，2021-2024年麻省理工学院机械工程系进行博士后研究。科研聚焦于可植入型柔性电子器件的研制及其在生物医学领域的应用，致力于加深人类对于基础神经科学的理解并为医学诊断和治疗的转化提供平台。在Nature Neuroscience、Science Robotics等发表论文30余篇，累计引用3000余次，论文入选全球前1%影响力文章并在泰晤士报、纽约时报等知名第三方学术评价平台报导。

报告摘要

Establishment of optogenetic protocols combined with high-resolution light delivery tools enable researchers to selectively modulate the activities of targeted neurons population. However, the device-level integrations of light delivery interfaces in the context of free-behaving animal experiments remain challenging. I will report the development of a device platform that combines flexible neural interfaces that engage the biological organism with μLED-induced optogenetic stimulations and a battery-free wireless dynamically programmable system that provides real-time control of stimulation parameters. Application of these devices, for the first time, realizes coordinative control on brain activities and achieve active dynamic control of social interaction tendencies. Meanwhile, these devices can generate artificial perceptions through spatiotemporally orchestrated transcranial optogenetic stimulations among selected cortical regions of the brain in behavior studies to investigate how distributed synthetic cortical activities are perceived.